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Top 5 Anti-Wrinkle Creams of 2022 That Really Work

Has your quest for living your most beautiful, healthy lifestyle sent you in search of the perfect anti-wrinkle cream? There are many to choose from, but so far in 2022, there are 5 that top the list. 

Best Anti-wrinkle Creams

Top Anti-Wrinkle Products - (Image Credit: Shutterstock)


The number of anti-wrinkle creams on the market is overwhelming. The global skincare market is nearly 1.5 billion dollars. We’re all interested in keeping our skin as healthy and youthful-looking as possible, and many of us are willing to pay a significant amount of money to achieve this goal.

Still, with so many anti-aging products on the market, and all the different ingredients they contain, choosing the best anti-wrinkle cream for your skin is a challenge. Mindfulness for healthy skin is pivotal, and that involves using only the best, truly effective creams and moisturizers on your skin.

Learn more about what makes an effective anti-wrinkle cream and the 5 best products on the market in 2022.

Common ingredients in Best Anti-Wrinkle Creams – What to Look For

  • Alpha-Hydroxy Acids– AHAs work as gentle exfoliants that loosen the “glue” that binds dead skin cells to the skin’s surface. They brighten skin tone and can help improve discolorations and the overall appearance of fine lines and wrinkles.
  • Peptides– Peptides are naturally occurring molecules. When applied to the skin, they may increase collagen production and improve texture and tone.
  • Hyaluronic Acid– Hyaluronic acid is a humectant that’s capable of holding 1000 times its weight in water. It helps attract and maintain a proper level of moisture for the skin.
  • Vitamin C– Vitamin C is a powerful antioxidant that protects the skin from oxidative stress and can help heal photodamage from the sun.
  • Retinol– Retinol is a derivative of vitamin A and shown to be effective in reducing the appearance of fine lines and wrinkles. Retinols work by stimulating collagen production, which naturally declines as we age.


How Do Anti-Aging Wrinkle Creams Work?

Contrary to popular belief, anti-aging wrinkle creams are not a magical elixir that immediately erases wrinkles forever as soon as they’re applied.

Some anti-aging products work beautifully for significantly reducing the appearance of wrinkles upon application but supporting and rejuvenating skin is a process that is more than skin deep.

Anti-aging wrinkle creams work in a couple of ways. First, as mentioned, they plump up surface skin cells, essentially filling in fine lines and wrinkles so they appear less visible.

Anti-aging wrinkle creams also provide hydration, which is essential for maintaining healthy skin and preventing premature aging. Many also contain active ingredients that are absorbed into the skin, penetrating into the deeper layers.

It’s here that they get to work increasing or supporting the production of collagen, elastin, and other key components of your skin’s support matrix.

Key Ingredients in Best Anti-Wrinkle Creams

Of the common anti-wrinkle cream ingredients listed above, you’re going to find that the most effective options on the market contain retinol, hyaluronic acid, or vitamin C. These are by far, the most well-respected ingredients used today.

This isn’t to say that if an anti-wrinkle cream doesn’t contain one of these key ingredients that it won’t do the job. Some anti-wrinkle creams contain ingredients such as acetyl hexapeptide-3, which has a similar effect as Botox, without introducing a toxic substance into your body.

It’s also important to look at the supporting ingredients. Natural, gentle ingredients like grape seed oil, jojoba oil, and tea tree extract can complement the active ingredients in anti-wrinkle creams without the irritating side effects of harsher synthetic ingredients.

The 5 Best Anti-Wrinkle Creams


1. Stemuderm


Stemuderm is a professional strength anti-wrinkle cream that supports the skin on multiple levels.

With ingredients that include acetyl-hexapeptide-8, jojoba seed oil, squalene, and hyaluronic acid, Stemuderm reduces the appearance of wrinkles.

It also helps maintain proper hydration, firms the skin, and improves facial muscle conditioning. Read our full review

2. LifeCell


LifeCell offers a complete anti-aging skincare system that includes their all-in-one Anti-Aging Treatment.

The goal of this product is to improve the skin’s appearance without a burdensome skincare routine.

LifeCell produces results with a formula that contains hyaluronic acid, peptides, retinol, and vitamin C. Read our full review

3. SiO Beauty

SiO Beauty

SiO Beauty takes a revolutionary approach to anti-aging skincare. Instead of your typical cream,

SiO Beauty uses medical-grade silicone patches to deliver incredible results.

The SiO FaceLift patch creates a healing microclimate between the skin and silicone which draws moisture up from the skin’s deepest layers. Read our full review

4. Crepe Erase

Crepe Erase

Crepe Erase offers a full line of anti-aging products for the face and body.

Along with natural, gentle ingredients like olive oil, grapeseed oil, and cocoa butter, Crepe Erase uses their unique Trufirm Complex that is said to be the powerhouse behind the product’s results. Read our full review

5. DermaWand


This isn’t exactly an anti-wrinkle cream but it is one of the most effective anti-aging skincare options on the market today.

DermaWand is a wand that uses radiofrequency to smooth the skin, reduce puffiness, stimulate cellular rejuvenation, and minimize the appearance of fine lines and wrinkles. Read our full review

Your Anti-Wrinkle Regimen

When deciding on the best anti-wrinkle regimen, it’s always good to start by speaking with a dermatologist to determine your unique skin care needs and goals.

That said, regardless of skin type, an effective anti-wrinkle regimen includes these key steps.

  • Hydration: Hydrate your skin from the inside and outside by drinking an adequate amount of water each day. Also, use a hydrating moisturizer formulated for your skin type.
  • Nourishment: Fuel your body with nutritious foods for glowing, vibrant skin.
  • Cleansing: Cleanse your skin with a gentle cleanser both morning and night.
  • Tone: Toners remove impurities, grab the last traces of cosmetics, and tighten pores.
  • Exfoliate: Choose a gentle, non-abrasive exfoliant, such as natural enzymes that lift dead skin cells from the skin. Regular exfoliation keeps skin looking fresh and healthy.
  • Moisturize: Finally, always moisturize your skin. Choose an anti-wrinkle moisturizing cream that contains targeted ingredients your skin needs.

Frequently Asked Questions

Skincare is a science. It can take scientists years of careful research, testing, and trials before putting forth a new skincare ingredient for review. Ingredients that truly work come to the market only after a significant investment in time and money has already been made. This cost carries through to the final product.

You’re also paying for quality ingredients. Harsh, unnecessary filler ingredients are inexpensive; however, a product made with a purer formula is going to cost more as a reflection of the costs that go into producing it.

That said, don’t take price alone as the sole indicator of a product’s effectiveness. There are high-end skincare products that don’t live up to expectations and less expensive ones that perform wonderfully.

It depends on the product you’re using. Some wrinkle creams come with ineffective ingredients that sit on top of the skin. These do nothing for the deeper, supportive structures of your skin.

Wrinkle creams that contain targeted ingredients that penetrate the skin can improve the skin’s tone, texture, and minimize the appearance of wrinkles. They can also provide a protective effect against future damage. Wrinkle creams aren’t miracle workers, however. They can improve the appearance of wrinkles but not make them disappear entirely.

Many factors influence how your skin ages. Well-respected research tells us that protecting our skin from the sun is one of the most important anti-aging skincare steps we can take. Another anti-aging tip is to embrace a healthy lifestyle that includes regular exercise, proper nourishment, and stress relief.

Investing in a daily skincare routine designed for your skin type is key for supporting your skin, keeping it healthy, and slowing down the inevitable aging process. All of these factors combined – sunscreen, a healthy lifestyle, and proper skincare is the winning approach.

A professional dermatologist would recommend products based on an individual’s skin type, problem areas, and skincare goals. Across the board, most dermatologists are going to recommend a gentle cleanser, toner, exfoliant, moisturizer, and targeted anti-aging skincare products. These might include hyaluronic acid, retinol, or vitamin C.

Loss of moisture plays a vital role in how skin ages. Hyaluronic acid is an essential element of the skin’s support matrix, and the amount found in the body decreases as we age. Topical hyaluronic acid may be able to decelerate skin aging, but the main way it helps with wrinkles is its humectant properties.

Hyaluronic acid can attract and retain 1000 times its weight in moisture. It helps maintain a healthy moisture level and a protective barrier to the skin. It also plumps up fine lines and wrinkles, making them less visible.

What are the differences between serum and cream?

The main difference between an antiaging serum and cream is the primary ingredients each one contains.

Serums are lighter, fluid, and a bit slippery in texture. Serums are more highly concentrated and have a more effective absorbency rate. The smallest amount of serum can penetrate deep within the skin to nourish and repair, depending on the active ingredients.
Antiaging Serum
Creams are thicker, have a higher concentration of lipid or fatty substances while containing less water than serums. Creams help maintain the skin’s moisture levels while keeping it soft and smooth.
woman applying body cream

Different Anti-Wrinkle Creams for Different Skin Types

Any singular anti-wrinkle cream isn’t going to work for all skin types. It’s important to choose one that works with your skin type, including paying attention to ingredients that might cause sensitivities.

There’s also a misconception that oily skin doesn’t need moisturizer. If you want to get rid of oily skin, using a properly formulated moisturizer can be one of your best strategies. A lightweight, water-based (meaning oil-free) moisturizer helps to maintain the hydration level of oily skin and prevent oil glands from over secretion due to the use of harsh acne control products.

If you have sensitive skin, look for moisturizers with gentle ingredients like hyaluronic acid that help protect the skin from moisture loss, plump up fine lines, and reduce irritation and inflammation.

Mature, dryer skin requires an oil-based moisturizing cream that penetrates below the surface of the skin to enhance the support matrix beneath. Ingredients such as retinol can stimulate collagen production and support younger-looking skin from the inside out.

Bottom Line

Mindfulness for healthy skin begins with a commitment to an anti-aging skincare routine. Anti-aging creams are an essential component of skincare, regardless of your skin type. Remember, that there is a price for quality; however, that doesn’t mean the most expensive creams are always the best. Instead, look at the formula to determine if a product is going to follow through on its promises.

Anti-aging wrinkle creams aren’t miracle workers. Even the most effective treatment can only do so much on its own. It’s up to you to take care of your skin from inside out if you want to see optimal results from the top anti-wrinkle creams of 2022.

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