Perricone MD Review – Does this Product Really Work?

4.3/ 5.0

Perricone MD is a beauty brand that may offer a wide range of skincare, makeup, and supplement products. It may adopt a holistic, three-tier skincare and wellness system for its products. Perricone MD has been around for nearly two decades now.


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Overview Of Perricone MD

Being beautiful and healthy at the same time has become something that everyone aspires to in the modern world irrespective of age, gender, or any other differences. Today there are many beauty brands and regimens that may be available in the market. However, there is a remarkable inclination towards products that may contain natural ingredients.
Perricone MD is a beauty and skincare brand that may present beauty products, supplements, and dietary plans incorporated with potent natural ingredients and formulations. 
Let’s examine what Perricone MD reviews reveal about this brand.

How Does Perricone MD Work?

Perricone MD makes use of formulations rich in natural antioxidants and nutrients that the body usually creates on its own. Since the body recognizes these ingredients as its own, it may respond quickly and show visible results early.

Who Is The Manufacturer Of Perricone MD?

Perricone MD is a brand created by Dr. Nicholas Perricone. He is a world-famous healthy aging expert, board-certified dermatologist, and Certified Nutrition Specialist (C.N.S.). He is also an award-winning inventor, philanthropist, and author of multiple New York Times bestsellers.

Dr. Perricone initially launched the brand as Clinical Creations in 1997 and later renamed it Perricone M.D. in 1998. The goal of the company is to deliver advanced skin care with the help of three tiers including, performing ingredients, patented sciences, and powerful results. It is currently based in San Francisco, California.

Perricone MD

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What Are The Ingredients In Perricone MD?

The primary active ingredients in Perricone MD are as follows.

Hyaluronic acid – This is a polyanionic natural polymer found in the connective tissues. Studies indicate that hyaluronic acid may alleviate dry skin, reduce wrinkles and minimize the appearance of fine lines. It may help retain moisture in the skin and delay skin aging.
Glutathione – This is a potent antioxidant that is naturally produced in the body. It may consist of three amino acids, glutamine, glycine, and cysteine. Studies show that glutathione may fight free radicals efficiently and provide protection from oxidative stress. It may also be useful against cancer, psoriasis, and diabetes-like metabolic disorders
Polypeptides – These are amino acid chains naturally found in the human body. They may contribute to making up proteins and collagen in the skin. Research data shows that these peptides may help improve the skin barrier and provide protection against pathogenic organisms, pollution, and ultraviolet rays. They may also reduce wrinkles, ease inflammation and improve the elasticity of the skin[1].
Vitamin C Ester – L-ascorbic acid is the chemically active form of vitamin C. It is naturally available in food sources like citrus fruits, papaya, and green leafy vegetables. It is a powerful antioxidant. It may prevent skin damage from free radicals and ultraviolet rays in the sun.
Vitamin E – This is a fat-soluble antioxidant that may provide many benefits to the skin. It may protect the skin from sun damage. It may also improve conditions like melasma, psoriasis, acne, atopic dermatitis and promote wound healing[2].
Dimethylaminoethanol/ DMAE – This is also known as Deanol and it is known for its ability to increase the synthesis of acetylcholine, a neurotransmitter that transmits signals between neurons. Studies show that DMAE has anti-inflammatory properties and it may reduce the appearance of coarse wrinkles, under-eye dark circles, and sagging of the skin.

The Science Behind Perricone MD

Perricone MD combines many potent antioxidant, anti-inflammatory, and hydrating ingredients. Individually, these ingredients are backed by extensive clinical and consumer studies.

The company lists clinical testing results regarding a few products on its official website. However, details regarding clinical trials that may be conducted on other products to prove their efficacy and safety as a whole are not widely available.

What Are The Benefits Of Perricone MD?

  • Perricone MD may present an extensive range of skincare and other beauty products/supplements.
  • Its products may be developed under the supervision of a board-certified dermatologist.
  • The Perricone MD may use ingredients backed by clinical testing.
  • The products of the company may improve skin hydration, prevent skin damage, and delay aging.

What Are The Drawbacks Of Perricone MD?

  • Perricone MD may not provide a free trial period.
  • The products of Perricone MD may be a bit on the pricier side of the spectrum as far as the cost of beauty products is concerned.
  • Its products may contain some artificial ingredients as well.
  • Perricone MD may not refund products that are opened or not in the original packaging.

FAQs: Consumer Questions & Answers

In our research for this report, we found that consumers are frequently asking the following questions online regarding Perricone MD.

Perricone MD products are manufactured under the supervision of Dr. Nicholas Perricone, a board-certified dermatologist and a Certified Nutrition Specialist (C.N.S.). Its products may be cruelty-free. However, the ingredients used in Perricone MD products are not entirely organic.

Perricone MD may be purchased from the manufacturer's official website and other beauty stores or retail stores. The products by Perricone MD may be priced at a premium range.

The ways of using Perricone MD products may vary according to the individual product specifications. Usually, the necessary instructions may be found on the packaging of the products.

There is no free trial for Perricone MD products. If the customers are not happy with their purchase, they may cancel the order or return the unopened product within 14 days of receipt.

Perricone MD may use a variety of novel ingredients and formulations in its product that makes them unique in their way.

There are no side-effects of Perricone MD products. However, ingredients like acyl-glutathione may irritate some of its consumers.

Looking at the Perricone MD reviews, it seems that products of this brand may be effective in what they claim to do. The company follows a holistic approach in which they may try to achieve beauty from the inside-out and outside-in.

What Are Consumers Saying About Perricone MD?

Many Perricone MD reviews express positivity about its products. Some of the products like Cold Plasma Plus+ have more positive feedback from customers than others. However, some users may have failed at experiencing any significant results after using the products as well.

As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.

Below you’ll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.

Rating Table Rating Table


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Stemnucell Stemnucell
  • Improves the Appearance of Fine Lines and Wrinkles*
  • Multi-Action Formulation*
  • Has a Light, Non-Greasy Texture*
  • Soothes Sensitive Skin*
  • Absorbs Quickly into Your Skin*

Overall Rating


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No7 Laboratories Firming Booster Serum
  • Improves the Appearance of Fine Lines and Wrinkles*
  • Multi-Action Formulation*
  • Has a Light, Non-Greasy Texture*
  • Soothes Sensitive Skin*
  • Absorbs Quickly into Your Skin*

Overall Rating


Read Full Review

Beau Skin Serum
  • Improves the Appearance of Fine Lines and Wrinkles*
  • Multi-Action Formulation*
  • Has a Light, Non-Greasy Texture*
  • Soothes Sensitive Skin*
  • Absorbs Quickly into Your Skin*

Overall Rating


Read Full Review

Your skincare routine is only as good as the products you use. Good, high-quality products are safe and effective and may come in particular formulations for sensitive skin and other issues. They can improve the texture and appearance of your skin while protecting it from the effects of the sun, pollutants, and other problems that can also have a negative impact on your health. Below you will find our subjective assessment of the Perricone MD based on the strength of the available information and our estimation of its efficacy for the Perricone MD.

Perricone MD
Perricone MD
  • Improves the Appearance of Fine Lines and Wrinkles*
  • Multi-Action Formulation*
  • Has a Light, Non-Greasy Texture*
  • Soothes Sensitive Skin*
  • Absorbs Quickly into Your Skin*

Overall Rating


Stemnucell - A Better Alternative?

Improves the Appearance of Fine Lines and Wrinkles*
Multi-Action Formulation*
Has a Light, Non-Greasy Texture*
Soothes Sensitive Skin*
Absorbs Quickly into Your Skin*

Stemnucell the lightly textured, easily absorbed serum not only provides deep hydration to eliminate dry skin quickly but offers long-term anti-aging benefits too for all skin types.

The dermatologist-developed, multi-action Stemnucell formula contains clinically proven key ingredients that, with regular use, work to repair existing damage as they simultaneously slow the skin aging process. While seaweed extract acts as an anti-inflammatory to soothe the skin and reduce irritation and Hyaluronic Acid adds volume to smooth away wrinkles, it is the inclusion of innovative growth enzymes that improve the health of skin cells for a long-lasting youthful appearance. Additionally, Stemnucell helps promote the production of essential collagen, improving elasticity and ensuring the skin remains plump and supple, even as it ages.

You can find out more about Stemnucell by reading our full review below.

Read More About Stemnucell Nowarrow

Final Words

Perricone MD may be a high-end beauty and skin care product manufacturer that creates a wide range of products from topical applications to dietary supplements. This brand makes use of a fusion of scientific knowledge and natural ingredients in its products. However, it may also contain artificial ingredients.

Looking at the Perricone MD reviews, it appears that the products of this brand may be safe for the most part. However, the outcome of using these products may vary according to the specific conditions of each product as well as its consumers.

**The above is a subjective review. Our opinion of the product’s efficacy was based on independent research and information.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

Disclosure of Material Connection : Products shown in the section titled ‘Our Top Choice’ are those that we promote as the owner and/ or reseller and does not represent all products currently on the market or companies manufacturing such products. This information is disclosed in accordance with the Federal Trade Commission’s 16 CFR, Part 255 “Guides Concerning the Use of Endorsements and Testimonials”. We would like to make it clear that any and all links featured in this section are sales links; whenever a purchase is made via one of these links, we will receive compensation.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.


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