AcuPlus Pain Relief Cream Reviews – Does This Product Really Work?

4.3/ 5.0

AcuPlus Pain Relief Cream is a topical analgesic cream formulated to ease joint pain and inflammation and muscle and nerve pain associated with arthritis, sore muscles, strains, sprains, and bruises, helping you start moving again.


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Overview of AcuPlus Pain Relief Cream

AcuPlus Pain Relief Cream is an OTC (over-the-counter), FDA-registered pain-relieving formula made for individuals who are exhausted from living with both minor aches and acute pain accompanied by common ailments, such as back pain, neck pain, shoulder pain, hip pain, knee pain, hand and wrist pain, foot and ankle pain, elbow pain, tendonitis, and bursitis.

After three years of clinical experiments with the support and feedback of more than 500 patients with pain, this revolutionary formula was invented by a board-certified rehabilitation physician and renowned chemist and is presently available to the health care industry and public. AcuPlus Pain Relief Cream was once highlighted on National Television.

Run through AcuPlus Pain Relief Cream reviews from previous users to help you decide whether it is a veracious product.

How Does AcuPlus Pain Relief Cream Work?

AcuPlus Pain Relief Cream utilizes a proprietary delivery system that penetrates clinically approved substances to the root source of inflammation with a high-quality proprietary blend of fourteen (14) organic ingredients, including Arnica, Magnesium, Vitamin B6, Vitamin E, Licorice Root, Willow Bark, Cetyl Myristoleate, Ilex, Yerba Mate, Tea Tree, among others.

All of these science-backed substances work together to promote healthy blood circulation, accelerate healing, and eradicate aches, pain, soreness, swelling, stiffness, and cramping caused by inflammation.

Arnica stimulates white blood cell activity that moves trapped fluids from the bruised tissue, muscles, and joints. Numerous studies have shown the effectiveness of Arnica in the treatment of osteoarthritis with the reduction of stiffness and pain.

Vitamin B6 may promote myelin formation, which is a protein layer forming around the nerve cells that attenuate nerve inflammation.

Who Is the Manufacturer of the AcuPlus Pain Relief Cream?

Produced in the USA in a QAI, Ul, and FDA-certified laboratory, the supplement is manufactured by the brand known as Innovations for Wellness, LLC.

This is a leading wellness business focused on producing health and wellness solutions. AcuPlus was initially developed by Dr. Craig Morton, a board-certified physical medicine and rehabilitation specialist and a national expert in spine care.

AcuPlus Pain Relief Cream

AcuPlus Pain Relief Cream Review – Health Web Magazine Images

What Are the Ingredients in AcuPlus Pain Relief Cream?

Cited below are the primary ingredients of AcuPlus Pain Relief Cream:

Glucosamine – Pilot studies have shown that this agent may develop and maintain cartilage within the joints, reduce inflammation via reduction of inflammatory mediators, and prevent joint and bone disorders.
MentholThe International Journal of Clinical Pharmacy and Therapeutics assert that menthol might generate cold allodynia and trigger central analgesic pathways to eliminate pain.
Aloe Vera – Packed with antioxidants, Vit A, C, and B12, choline, and folic acid, aloe vera may fight free radical damage, ease inflammation and muscle pain, and protect and hydrate your skin.
MSM (Methylsulfonylmethane) – It is capable of repairing the permeability of cell walls, allowing fluids to move through tissues with comfort and eliminating toxins and lactic acids. This helps to equalize pressure in joints and muscles.
Boswellia Serrata – The agent may possess analgesic, anti-inflammatory[1], and anti-arthritic activities and reduce knee pain, walking pain, and movement disability associated with osteoarthritis.

The Science Behind AcuPlus Pain Relief Cream

The cream contains menthol that may bind to temperature-sensitive receptors within your skin. These receptors may modulate pain signals by your body’s pain-relieving system.

Research explains menthol could encourage cold receptors within your skin that might help moderate pain. This process is called cryotherapy, also known as cold therapy.

AcuPlus Pain Relief Cream produces a cold sensation that supersedes painful signals to your brain. According to the Gate Control Theory, nerve impulses from the stimulus block nerve gates to the painful input, which prevents pain signals from traveling to your Central Nervous System (CNS), thereby eliminating pain.

Conversely, Archives of Dermatological Research[2]proclaim menthol does not affect pain sensation during clinical trials.

What Are the Benefits of AcuPlus Pain Relief Cream?

  • The cream may provide relief from athletic pain.
  • It may calm muscle and nerve pain.
  • It may ease joint pain, overcome stiffness, and reduce cramping.
  • The topical formula may reduce swelling after prolonged activities.
  • It might relax your muscles for improved sleep.
  • It is non-staining, non-greasy, and free from steroids and gluten.

What Are the Drawbacks of AcuPlus Pain Relief Cream?

  • Discount bundles are not available.
  • Samples are not offered by the makers.
  • No clinical trials support the efficacy of this product.
  • Some buyers may experience itching or redness.

FAQs: Consumer Questions & Answers

In our research for this report, we found that consumers are frequently asking the following questions online in regard to AcuPlus Pain Relief Cream.

Do not keep it close to flame or heat. Avoid contact with the mucous membranes or eyes. Do not apply to damaged and irritated skin or wounds.

Do not use other sprays, creams, and ointments. Do not try to bandage the area where you apply the product. Do not use a heating device or pad. After use, wash your hands with cool water. Discontinue this product and ask your physician if the condition worsens or symptoms continue for more than seven days.

AcuPlus Pain Relief Cream is moderately priced.

Apply the cream in generous amounts to the affected skin and massage thoroughly for about 30 seconds to 1min until fully absorbed into your skin. Use this cream up to 4-5 times a day for at least 8-12 days. After that, use only when needed.

Customers are eligible for a pain-free refund policy; they will not even have to return their product.

Most menthol preparations are poorly tolerated because of their intensity and a deficit of cooling properties.

No side effects are specified on the official page of the product.

AcuPlus Pain Relief Cream reviews from buyers are somewhat mixed.

What Are Consumers Saying About AcuPlus Pain Relief Cream?

AcuPlus Pain Relief Cream reviews reveal that a proportion of users have noticed changes in their flexibility, strength, and pain level, while some said the product claims do not match the reality as it did not help them at all. It causes extreme itching to one user.

Bones are connected by joints, which allow us to move with ease. Joint damage can cause pain preventing you from doing the things you once loved. Topical joint relief supplements tend to work more quickly, helping to relieve pain directly in the affected area compared to supplements taken orally. A topical joint pain relief supplement should be evaluated on its: potential to block the transportation of pain signals, potential to act as a counterirritant to reduce soreness, potential to act as a counterirritant to reduce soreness and quality of Ingredients backed by clinical research.

Below you’ll find some of the most effective topical joint pain supplements on the market today, in our opinion.

Rating Table Rating Table

Our Top Products

Try it now
Flexdermal Flexdermal Rating
  • All-Natural, Clinically Tested Formula*

  • Reduces Joint Pain & Inflammation*

  • Enhances Joint Mobility & Range of Motion*

  • Eases Stiffness & Increases Flexibility*

  • Prevents Recurring Damage*


  • Quickly reduces all types of joint pain
  • Starts working upon application
  • Relieves inflammation & stiffness
  • Enhances overall flexibility & mobility
  • Can be used wherever pain occurs
  • Fast-absorbing formula with no greasy residue
  • Non-irritating & safe for all skin types
  • Safe to apply several times a day
  • Beneficial for easing muscle soreness
  • 100% natural, safe formula
  • Has a generous 60-day money-back guarantee
  • Customers are not required to sign up for an auto-shipping delivery plan


  • Flexdermal is only sold online
  • Stock is sometimes low due to high consumer demand

The Bottom Line

Joint pain is something that affects numerous men and women, and whether it’s an occasional twinge once in a while or a more serious, ongoing problem, finding fast, effective relief is imperative. We looked at numerous brands of topical joint pain products to compile a list of the top five, and at the end of the process, we were left with no doubt that Flexdermal is the best choice for consumers.



This high-quality, doctor-developed cream works on all aspects of joint pain, quickly reducing inflammation, alleviating stiffness, and promoting a healthy flow of blood to the affected area almost immediately upon application. The proven active ingredients contained in the maximum strength Flexdermal formula penetrate quickly, safely numbing the pain-signaling nerves and targeting the root cause of the problem for long-lasting relief. Additionally, it is equally beneficial in easing the pain from overworked muscles, providing a comforting, warming sensation to whatever part of the body it’s applied, alleviating aching and soreness.

Flexdermal is extremely fast-absorbing, so once it’s applied, you can dress and get on with your day without having to wait for it to sink in. Because it’s an all-natural product with no harmful chemical substances, Flexdermal can even be used by individuals with easily irritated skin, and unlike some creams of this type, it doesn’t have an overpowering medicinal scent. It can be applied several times a day if required, and there have been no reports of any side effects, even with long-term use.



Flexdermal is produced in a state-of-the-art facility that adheres to all safety and quality control regulations, and the manufacturer offers a full 60-day money-back guarantee on every order, which shows just how confident they are that their product will produce the fast-acting results that they know their customers want.

No one should have to live with the pain of stiff, inflamed joints or sore muscles and with Flexdermal, they don’t need to. In our opinion, this brand is the best topical joint pain cream on the market as it checks all our boxes for quality ingredients, safety, pricing, satisfaction guarantee, and of course, the ability to reduce pain almost immediately upon application!

Australian Dream
#2 Australian Dream
  • All-Natural, Clinically Tested Formula*

  • Reduces Joint Pain & Inflammation*

  • Enhances Joint Mobility & Range of Motion*

  • Eases Stiffness & Increases Flexibility*

  • Prevents Recurring Damage*


  • Product comes in a convenient creamy formula
  • Purchase packages are offered


  • Product comes in a convenient creamy formula
  • Purchase packages are offered

The Bottom Line

Australian Dream Cream is a topical joint product that can ease discomfort in the joints and muscles. However, joint pain is something that needs to be taken seriously, so taking time to consider all options before purchasing any joint care product is essential to choose what suits your individual needs.

Osteo Bi-Flex
#3 Osteo Bi-Flex
  • All-Natural, Clinically Tested Formula*

  • Reduces Joint Pain & Inflammation*

  • Enhances Joint Mobility & Range of Motion*

  • Eases Stiffness & Increases Flexibility*

  • Prevents Recurring Damage*


  • All ingredients are listed
  • All company contact details are shown
  • There is FAQ section


  • All ingredients are listed
  • All company contact details are shown
  • There is FAQ section

The Bottom Line

Osteo Bi-Flex does contain some key ingredients that have a history of use in reducing joint pain, but without seeing the individual ingredient description the overall potency of the formula is not known. While the website gives an overall good impression of the cream, there are very few relevant details provided and it would be helpful not only to be given more information about the formula for Osteo Bi-Flex but customer success stories and clinical testing results too. While the manufacturer does appear to be reputable and established, it’s a concern that they don’t provide more details about their background or provide in-depth information regarding the quality and benefits of the ingredients used in the J Osteo Bi-Flex ointFlex formula. Any consumer that wants to try this cream should certainly contact the company directly for full terms and conditions of the money back guarantee before making an order.

Dietary supplement recommendations can be found everywhere — in commercials, through social media influencers, and from your neighbors, friends, and family. With so many different opinions, it can be hard to know which supplement is right for you. While most quality supplements undoubtedly provide health benefits, each will work in its own unique way, so it's important to determine which one will help you reach your health goals. Below you will find our subjective assessment of AcuPlus Pain Relief Cream based on the information available to us and our estimation of its overall efficacy.

AcuPlus Pain Relief Cream
AcuPlus Pain Relief Cream
  • All-Natural, Clinically Tested Formula*
  • Reduces Joint Pain & Inflammation*
  • Enhances Joint Mobility & Range of Motion*
  • Eases Stiffness & Increases Flexibility*
  • Prevents Recurring Damage*

Overall Rating

Try It

Flexdermal - A Better Alternative?

All-Natural, Clinically Tested Formula*
Reduces Joint Pain & Inflammation*
Enhances Joint Mobility & Range of Motion*
Eases Stiffness & Increases Flexibility*
Prevents Recurring Damage*

Flexdermal is a potent topical joint cream that starts working quickly, continuing to improve overall joint health by 98% within just 49 days!

The Flexdermal all-natural, maximum strength formula absorbs fast, without leaving any greasy residue. Its powerful blend of clinically proven ingredients reduces stiffness and increases flexibility in all joints, and is also highly effective for easing aching and sore muscles.

You can find out more about Flexdermal by reading our full review below.

Read More About Flexdermal Nowarrow

Final Words

AcuPlus Pain Relief Cream claims to provide quick pain relief and improve the range of motion in disabled parts. It might decrease stiffness and muscle spasms and warm up your muscles for maximum recovery and performance.

While the official website provides an overall good impression of the product, there is no information about clinical testing results.

Trial products are not available. AcuPlus Pain Relief Cream reviews depict both happy and unhappy customers. About a quarter of the reviews are negative and the nature of criticisms is bothersome. Buyers should speak with a physician rather because individual results may differ.

**The above is a subjective review. Our opinion of the product’s efficacy was based on independent research and information. *Results from using this product may vary. If you have a serious medical condition, a history of heart conditions, are pregnant or nursing, we recommend that you speak to your healthcare provider before using this, or any other health product and/ or supplement. The content provided on Health Web Magazine is only intended for your informational purposes and should not be regarded as a substitute for advice from a healthcare professional. It should not be used to diagnose, treat, cure, or prevent any health condition, and we will not be held responsible for any complications that may arise from you using it for any of those aforementioned reasons. All concerns regarding your personal health must be dealt with directly by your healthcare provider.

Disclosure of Material Connection : Products shown in the section titled ‘Our Top Products’ are those that we promote as the owner and/ or reseller and does not represent all products currently on the market or companies manufacturing such products. This information is disclosed in accordance with the Federal Trade Commission’s 16 CFR, Part 255 “Guides Concerning the Use of Endorsements and Testimonials”. We would like to make it clear that any and all links featured in this section are sales links; whenever a purchase is made via one of these links, we will receive compensation.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

† Based on an internal customer response survey of subgroups of individuals. This is a subjective survey and in no way should it be intended to be interpreted as a clinical study. Results may vary.


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