Fact Checked

Defenage Review – Does This Product Really Work?

Defenage is an anti-aging eye cream designed to reduce aging signs such as drooping eyelids, dark circles, crow’s feet, and puffiness.


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Overview Of Defenage

According to the brand, this anti-aging eye cream is formulated with a combination of ingredients, including a proprietary blend known to noticeably improve the appearance of aging skin in the eye area.

The proprietary blend Age Repair Defensins is said to reverse the signs of skin aging by stimulating the body’s dormant stem cells. This causes it to produce new skin and correct cosmetic concerns in the eye area by firming, visible lifting, fading of dark circles, and diminishing the appearance of crow’s feet and fine lines.

The product is sold on the official website and significantly higher-priced than many similar formulations for aging eyes.

Here, we will review the claims of Defenage, the ingredients, pricing, possible adverse reactions, pros and cons of usage, and manufacturer details. Defenage reviews will also be considered for firsthand user experiences alongside other details to help buyers conclude it.

How Does Defenage Work?

As we age, facial aging signs such as crow’s feet, sagginess, hyperpigmentation, and eye bags are inevitable. And while products that claim to diminish these signs are formulated every time, very few live up to expectations. DefenAge claims to be one of the few effective products for aging eyes.

According to the brand, the 3D Eye Radiance Cream is an effective treatment for dark circles, fine lines, wrinkles, droopy eyelids, crow’s feet, and saggy skin. The product is claimed to soothe, firm, and smooth these areas without causing side effects such as redness and irritation.

It is also claimed to be suitable for all skin types and free of common irritants such as parabens, fragrance, gluten, and propylene glycol.

Who Is The Manufacturer Of Defenage?

The anti-aging eye serum is manufactured by DefenAge, a California-based cosmetics brand established in 2014 by a team of regenerative medicine experts.

Their products are formulated with Defensins, a proprietary blend to naturally awaken dormant skin cells and set off a wound-healing response to create a new skin for a younger-looking and healthier appearance.

Their products are sold officially by “authorized professionals” and on the brand’s website, where it enjoys many reviews from users. We must mention that their products are also significantly higher-priced than many similar products, even though reviewers on the website did not seem bothered by the price.


DefenAge Review – Health Web Magazine Images

What Are The Ingredients In DefenAge?

Outlined and discussed below are the active components of the eye formulation:

Defensins/Age-Repair Defensins Defensins are natural molecules/peptides rich in amino acid cysteine. They are known to play a vital role against invading microbes such as bacteria, viruses, and fungi by binding to their membranes and increasing their permeability.

In this eye cream, the defensins are identical copies of human defensins and made via biosynthesis and supposed to signal the body to create new skins by activating the dormant reserves of fresh and young cells.

Hyaluronic Acid – HA is often included in anti-aging formulations for its hydration-improving and skin-smoothing effects needed by aging skin.

In several studies, hyaluronic acid[1] has been shown to increase the body’s moisture levels, improve the appearance of wrinkles and fine lines and speed up wound healing.

Other ingredients in the formula include their “protected, advanced and powerful blend of natural extracts, antioxidants, and soothing technology.”

The Science Behind DefenAge

According to the brand, their scientific and clinical data indicates that their Age-Repair Defensins uniquely reprogram aging skin by targeting the skin’s stem cells to reverse common visible aging signs.

They also claim that in their clinical studies on the 3D Eye Radiance Cream, they have seen dark circles and puffiness under the eyes reduced alongside fine lines and crow’s feet on upper and lower eyelids without causing irritations.

While there are no known independent studies on the proprietary blend, most of the other ingredients have been clinically studied and found to hold the claimed benefits but not without some side effects.

What Are The Benefits Of DefenAge?

  • The cream may lift, smooth, and firm aging skin.
  • It may deeply hydrate the skin, giving it more volume.
  • Using the cream daily may improve skin tone and appearance.
  • It may eliminate the appearance of wrinkles, dark spots, and fine lines.

What Are The Drawbacks Of DefenAge?

  • No free trials are offered on the product.
  • Some users may experience mild skin irritation.
  • There are no independent studies on the cream.
  • Not everyone may like the smell of the product.
  • It is more expensively priced than many similar formulations.

FAQs: Consumer Questions & Answers

In our research for this report, we found that consumers are frequently asking the following questions online in regard to DefenAge.

DefenAge contains ingredients known to fight off aging signs and improve the appearance of aging skin. However, unless otherwise advised by a dermatologist, it is not recommended for people younger than 18. It is also not recommended for use on broken/unhealed skin and those with sensitivity to the ingredients. As with all topical skincare formulations, users are advised to rinse the product immediately and thoroughly with water if it enters the eyes.

While the product is expensively priced compared to many similar formulations, it is within the price range of some. Buyers also get a discount on the product upon registering for a free account.

The brand’s recommended direction for usage is as follows: For both morning and evening use. After cleansing and rinsing the skin, apply a pump of the cream onto the applicator, then gently dab three dots of the cream above and below each eye. With your hands or the applicator, massage cream thoroughly around the eyes.

No free trials are offered on the product. The brand accepts returns and provides refunds on products returned within a few days of order arrival. To qualify, the products must have been purchased directly on the official website and through “authorized professionals.” Refunds are made within two business days after items are received at the company’s office.

DefenAge is similar to some anti-aging eye cream in a lot of ways. It contains ingredients found in many alternatives. And even though the content of the proprietary blend is unknown, it is made by a known manufacturer and has several studies backing the claims of its main ingredients. However, while it shares similarities in pricing with some products, it is has a price higher than many alternatives.

While not common, some of the ingredients like the HA may cause redness, itching, swelling, and bruising.

The product contains ingredients known to help reduce aging signs around the eyes. While certainly far from being the cheapest eye cream, it seems to work, free of potentially harmful additives, and manufactured by a known brand.

What Are Consumers Saying About DefenAge?

DefenAge reviews have been mostly positive, especially those on the brand’s official website. Many of the reviewers claimed to have seen visible lifting effects, firming and smoothing of the skin around the eyelids, and a reduction in the appearance of discoloration, crow’s feet, fine lines, and puffiness.

On the other hand, reviews on some independent sites have been mixed, with some saying it did not do much for them.

As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.

Below you’ll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.

Our Top Choices of 2021


StemudermBest-Selling Anti-Wrinkle Dermatological Formula!

Stemuderm Reviews
4.5/5 (8327 Ratings)
Diminishes Wrinkles & Fine Lines 98%
Promotes Skin Cell Regeneration 99%
Boosts Hydration 98%
Promotes Good Skin Health 98%
Improves Skin Tone & Texture 97%


  • Produces visible results in less than 2 weeks
  • 100% of users experienced a reduction in wrinkle depth
  • Firms skin and restores elasticity
  • Provides long-lasting hydration to eliminate dryness
  • Supports an increase in collagen and elastin production
  • Reduces repetitive muscle movements to stop wrinkle development
  • Strengthens the protective skin barrier
  • Drastically improves long-term skin health
  • Prevents damage from toxins, pollutants, and environmental factors
  • Can be used on all skin types, including sensitive
  • All key ingredients are backed by solid clinical data
  • Manufacturer offers a full money-back guarantee and free shipping
  • Customers can try the product by ordering the Quick Starter Travel Pack
  • Customers do not have to sign up for an auto-shipment or subscription plan


  • Stemuderm cannot be purchased in retail stores
  • High consumer demand results in low stock occasionally

The Bottom Line

We looked at numerous brands of wrinkle creams during our process of compiling a list of the top brands on the market, but one treatment stood out from all the others, and that’s Solvaderm’s Stemuderm.

It’s no surprise that Stemuderm is one of Solvaderm’s best selling products when you consider that it visibly improves the appearance of the skin in less than 2 weeks of use! Rich in clinically proven key active ingredients, this dermatologist developed cream works on multiple signs of aging, including deep-set wrinkles across the forehead and around the mouth, fine lines and crow’s feet around the eyes, and even areas of hyperpigmentation such as age spots. Not only that, but within only a few applications, Stemuderm eliminated dry, flaky patches, locking in moisture, and making the skin smooth, hydrated, and soft to the touch.

Because Stemuderm produces powerful results in such a short period of time, it’s quickly become a consumer favorite with a satisfaction rating of more than 97%. Almost all Stemuderm users say that it’s an essential part of their morning and evening skincare routine and they would never stop using it. Indeed, the individuals who tested the cream as part of our own extensive review process said that they were particularly impressed at how easily Stemuderm could be incorporated into their current regimen, regardless of their skin type. They also noted that, with regular use, Stemuderm not only maintained the dramatic anti-aging effects they’d already achieved within the first initial few weeks of use but continued to improve the overall health and appearance of their skin, making it look refreshed and rejuvenated. Additionally, their complexion became evenly toned, with a complete absence of redness, and a more uniform texture.

Stemuderm Before After

When you look at the incredible results of clinical studies performed on the key active ingredients contained in Stemuderm, it’s easy to see why this treatment works as well as it does, with 100% of users seeing a drastic improvement after only a few weeks of use. For example, in one study looking at the anti-aging benefits of Matrixyl 3000, a substance that supports the production of collagen and elastin, participants experienced a 45% reduction in the area occupied by wrinkles. and in another scientific trial, women using a cream containing the peptide Acetyl Hexapeptide-8, demonstrated a decrease in wrinkle depth by as much as 60% within just 30 days.

While it is appreciated that the manufacturer of Stemuderm, Solvaderm, offers a money back guarantee on all their products including this one, we doubt that anyone would have a reason to return it. More than just a wrinkle cream, this truly is a multi-action skin treatment that can be used by individuals of all ages, whether they want to reverse existing damage and restore a youthful complexion, or prevent lines, wrinkles, and discoloration from developing in the first place.


Stemuderm customer reviews over the internet

Stemuderm Reviews
4.5/5 (8327 Ratings)
“My Skin Feels Silky Smooth, Young, And Lively, Thanks To Stemuderm!”

Sherri L., Age 47

  • Jo K.

    A Little Goes A Long Way

    Jo K. five-stars

    “In the past anytime I purchased an antiaging facial cream I would slather on thick amounts of it on my face in hopes of getting a superior result, but in reality, it turns out that it doesn’t really make a difference. Since I started using Stemuderm the first appreciate it was the fact that it does not take a large amount to get the job done. In fact, an amount smaller than a quarter is sufficient for application to your entire face. Of course, it also has to be very effective at doing its job or as I wouldn’t even be using it. It is excellent at hydrating my skin, and overall the appearance of fine lines around my eyes and mouth have been minimized. You do need to be consistent in using it, however, I learned this the hard way because I was using it once every couple of days and was not seeing anything, but once I started using it daily the results quickly became noticeable.”


#2.Miami MD

(4.2/5) 4625 Reviews
Diminishes Wrinkles & Fine Lines 89%
Promotes Skin Cell Regeneration 90%
Boosts Hydration 87%
Promotes Good Skin Health 88%
Improves Skin Tone & Texture 87%


  • Has many positive customer reviews
  • It was formulated by doctors


  • It is only available from the official website
  • The customer service department may be hard to contact
  • It may irritate sensitive skin
  • Ingredient amounts aren’t disclosed

The Bottom Line

Overall, the anti-aging treatment Miami MD appears to be a well-made and not overly expensive cream that provides multiple benefits for the skin. However, there are some negative aspects regarding the product too, with reports of it causing irritation for individuals with sensitive skin, and even a few consumers saying it made their complexion dry, which is the opposite of what a cream of this type should do. It would also be helpful if the manufacturer offered free samples of their cream and while there is a refund policy, some individuals have said that contacting the company’s customer service department is difficult.


#3. Drmtlgy

(3.9/5) 4235 Reviews
Diminishes Wrinkles & Fine Lines 88%
Promotes Skin Cell Regeneration 84%
Boosts Hydration 85%
Promotes Good Skin Health 83%
Improves Skin Tone & Texture 82%


  • Products in the range are suitable for all skin types
  • There is a 60-day money back guarantee


  • Drmtlgy products aren’t available in retail stores
  • Clinical study data for product formulas is not available
  • Drmtlgy is more expensive than comparable brands
  • Independent customer reviews are limited

The Bottom Line

The Drmtlgy brand offers several different skincare treatments, including a cleanser, SPF cream, and Needle-less serum, which according to the manufacturer is their best-selling product. The website for the brand is well-produced and reasonably informative and the formulas certainly contain some popular anti-aging key ingredients. However, the products are more expensive than similar brands and there is no solid evidence of successful clinical results provided on the website for prospective customers to review before making a purchase.


- Defenage Customer Reviews
  • Meghan: Light and clean cream, love it. Good effective product.
    Star Ratings
  • Iliana: Great Skin Repair Cream. Best cream for sensitive skin.
    Star Ratings
  • Valery: Love it. Made my skin wrinkle free. For smooth and wrinkle free skin.
    Star Ratings
  • Alisson: Reasonably priced and really effective. Loved the product performance.
    Star Ratings
  • Jovie: Changed the texture of skin in a week. Impressive product.
    Star Ratings
  • Whitley: My face feels so good after using this product. Very very nice amazing product.
    Star Ratings

Final Words

DefenAge is an anti-aging eye cream formulated with ingredients that may stimulate dormant skin cells, nourish, and fight off aging signs. The product is made by a known brand, claimed to be free of additives, and enjoys many reviews on the official website even though expensively priced. While DefenAge reviews on some independent sites have been mixed, many reviewers claim to have noticed improvements in their aging signs within just weeks of use. We advise that potential buyers do their due diligence before purchase if DefenAge is within their budget. If not, you can check out other similar products and pick a more suitable alternative.

**The above is a subjective review. Our opinion of the product’s efficacy was based on independent research and information.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

Disclosure of Material Connection : Products shown in the section titled ‘Our Top Choice’ are those that we promote as the owner and/ or reseller and does not represent all products currently on the market or companies manufacturing such products. This information is disclosed in accordance with the Federal Trade Commission’s 16 CFR, Part 255 “Guides Concerning the Use of Endorsements and Testimonials”. We would like to make it clear that any and all links featured in this section are sales links; whenever a purchase is made via one of these links, we will receive compensation.

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Defenage Review – Does This Product Really Work?
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Defenage Review – Does This Product Really Work?
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