Defenage Review – Does This Product Really Work?

4.3/ 5.0

Defenage is an anti-aging eye cream designed to reduce aging signs such as drooping eyelids, dark circles, crow’s feet, and puffiness.


Advertising Disclosure

FTC Disclosure

As the owner/sponsor of this e-commerce website, we have the full intention to be compliant with the Federal Trade Commission (FTC) rules about the use of testimonials, endorsements, and overall content in advertising and marketing. Accordingly, we want you as a visitor to understand the instances where we get paid to promote and sell products on this site. In full compliance with the FTC guidelines, please assume that any and all links on the website and/or table are sales links, and we receive compensation if you make a purchase through our website.

Our Top Selections Box - Promotional Advertising Content

The table below identified "Our Top Products" does not include all companies or all available products in the market. The content appearing on this page is branded advertising marketing content where we have a financial interest as the owners of the first product listed in the "Our Top Products" table, and as promoters and/or affiliates of the other products also listed within it. We are independently owned and the opinions expressed here are our own. All content is written without prejudice or bias, regardless of our advertorial product sponsor associations.

The content that appears on this page is presented as a nominative use product overview. Our subjective assessment of a product is based on the strength of the available information and our estimation of its efficacy. The provided information includes product information, overviews, buying guides, and product specifications. The information contained on this website is intended to educate and inform you of natural products designed to help improve your health and not to treat, cure, prevent or modify any disease. Trademarks, registered trademarks, and service-marks mentioned on this site are the property of their respective owners. If any content is factually inaccurate please contact us through this website and let us know so that we can address it appropriately. Contributing your product facts helps to better serve our readers and the accuracy of the content.

Overview Of Defenage

According to the brand, this anti-aging eye cream is formulated with a combination of ingredients, including a proprietary blend known to noticeably improve the appearance of aging skin in the eye area.

The proprietary blend Age Repair Defensins is said to reverse the signs of skin aging by stimulating the body’s dormant stem cells. This causes it to produce new skin and correct cosmetic concerns in the eye area by firming, visible lifting, fading of dark circles, and diminishing the appearance of crow’s feet and fine lines.

The product is sold on the official website and significantly higher-priced than many similar formulations for aging eyes.

Here, we will review the claims of Defenage, the ingredients, pricing, possible adverse reactions, pros and cons of usage, and manufacturer details. Defenage reviews will also be considered for firsthand user experiences alongside other details to help buyers conclude it.

How Does Defenage Work?

As we age, facial aging signs such as crow’s feet, sagginess, hyperpigmentation, and eye bags are inevitable. And while products that claim to diminish these signs are formulated every time, very few live up to expectations. DefenAge claims to be one of the few effective products for aging eyes.

According to the brand, the 3D Eye Radiance Cream is an effective treatment for dark circles, fine lines, wrinkles, droopy eyelids, crow’s feet, and saggy skin. The product is claimed to soothe, firm, and smooth these areas without causing side effects such as redness and irritation.

It is also claimed to be suitable for all skin types and free of common irritants such as parabens, fragrance, gluten, and propylene glycol.

Who Is The Manufacturer Of Defenage?

The anti-aging eye serum is manufactured by DefenAge, a California-based cosmetics brand established in 2014 by a team of regenerative medicine experts.

Their products are formulated with Defensins, a proprietary blend to naturally awaken dormant skin cells and set off a wound-healing response to create a new skin for a younger-looking and healthier appearance.

Their products are sold officially by “authorized professionals” and on the brand’s website, where it enjoys many reviews from users. We must mention that their products are also significantly higher-priced than many similar products, even though reviewers on the website did not seem bothered by the price.


DefenAge Review – Health Web Magazine Images

What Are The Ingredients In DefenAge?

Outlined and discussed below are the active components of the eye formulation:

Defensins/Age-Repair Defensins Defensins are natural molecules/peptides rich in amino acid cysteine. They are known to play a vital role against invading microbes such as bacteria, viruses, and fungi by binding to their membranes and increasing their permeability.

In this eye cream, the defensins are identical copies of human defensins and made via biosynthesis and supposed to signal the body to create new skins by activating the dormant reserves of fresh and young cells.

Hyaluronic Acid – HA is often included in anti-aging formulations for its hydration-improving and skin-smoothing effects needed by aging skin.

In several studies, hyaluronic acid[1] has been shown to increase the body’s moisture levels, improve the appearance of wrinkles and fine lines and speed up wound healing.

Other ingredients in the formula include their “protected, advanced and powerful blend of natural extracts, antioxidants, and soothing technology.”

The Science Behind DefenAge

According to the brand, their scientific and clinical data indicates that their Age-Repair Defensins uniquely reprogram aging skin by targeting the skin’s stem cells to reverse common visible aging signs.

They also claim that in their clinical studies on the 3D Eye Radiance Cream, they have seen dark circles and puffiness under the eyes reduced alongside fine lines and crow’s feet on upper and lower eyelids without causing irritations.

While there are no known independent studies on the proprietary blend, most of the other ingredients have been clinically studied and found to hold the claimed benefits but not without some side effects.

What Are The Benefits Of DefenAge?

  • The cream may lift, smooth, and firm aging skin.
  • It may deeply hydrate the skin, giving it more volume.
  • Using the cream daily may improve skin tone and appearance.
  • It may eliminate the appearance of wrinkles, dark spots, and fine lines.

What Are The Drawbacks Of DefenAge?

  • No free trials are offered on the product.
  • Some users may experience mild skin irritation.
  • There are no independent studies on the cream.
  • Not everyone may like the smell of the product.
  • It is more expensively priced than many similar formulations.

FAQs: Consumer Questions & Answers

In our research for this report, we found that consumers are frequently asking the following questions online in regard to DefenAge.

DefenAge contains ingredients known to fight off aging signs and improve the appearance of aging skin. However, unless otherwise advised by a dermatologist, it is not recommended for people younger than 18. It is also not recommended for use on broken/unhealed skin and those with sensitivity to the ingredients. As with all topical skincare formulations, users are advised to rinse the product immediately and thoroughly with water if it enters the eyes.

While the product is expensively priced compared to many similar formulations, it is within the price range of some. Buyers also get a discount on the product upon registering for a free account.

The brand’s recommended direction for usage is as follows: For both morning and evening use. After cleansing and rinsing the skin, apply a pump of the cream onto the applicator, then gently dab three dots of the cream above and below each eye. With your hands or the applicator, massage cream thoroughly around the eyes.

No free trials are offered on the product. The brand accepts returns and provides refunds on products returned within a few days of order arrival. To qualify, the products must have been purchased directly on the official website and through “authorized professionals.” Refunds are made within two business days after items are received at the company’s office.

DefenAge is similar to some anti-aging eye cream in a lot of ways. It contains ingredients found in many alternatives. And even though the content of the proprietary blend is unknown, it is made by a known manufacturer and has several studies backing the claims of its main ingredients. However, while it shares similarities in pricing with some products, it is has a price higher than many alternatives.

While not common, some of the ingredients like the HA may cause redness, itching, swelling, and bruising.

The product contains ingredients known to help reduce aging signs around the eyes. While certainly far from being the cheapest eye cream, it seems to work, free of potentially harmful additives, and manufactured by a known brand.

What Are Consumers Saying About DefenAge?

DefenAge reviews have been mostly positive, especially those on the brand’s official website. Many of the reviewers claimed to have seen visible lifting effects, firming and smoothing of the skin around the eyelids, and a reduction in the appearance of discoloration, crow’s feet, fine lines, and puffiness.

On the other hand, reviews on some independent sites have been mixed, with some saying it did not do much for them.

As we age the composition, texture and appearance of our skin changes. Signs of skin aging include wrinkles, fine lines, loss of moisture, uneven tone, and dull, tired-looking skin. There are countless anti-wrinkle creams on the market promising to make skin look and feel younger. Many anti-wrinkle creams promise everything short of a facelift or to provide the much sought after "fountain of youth". In reality most are just moisturizers marketed as anti-aging products.

Below you’ll find some of the most effective wrinkle serum/cream formulations on the market today, in our opinion.

Rating Table Rating Table

Our Top Products

Try it now
Stemuderm Stemuderm Rating
  • Diminishes Wrinkles & Fine Lines

  • Promotes Skin Cell Regeneration

  • Boosts Hydration

  • Promotes Good Skin Health

  • Improves Skin Tone & Texture


  • In a survey, 89% Of users saw a dramatic decrease in wrinkle depth within the first 4 weeks of using Stemuderm
  • Stemuderm targets the 12 visible signs of aging
  • 97% of users showed a reduction in the appearance of fine lines within just 4 weeks
  • Deeply moisturizes the skin to combat dryness
  • 81% of users showed a reduction in the appearance of crow's feet within the first 4 weeks
  • Increases the production of collagen and elastin
  • Safely inhibits muscle contractions to prevent wrinkles from forming
  • Repairs damage to the skin barrier
  • Boosts the overall health of the skin
  • Protects the skin from environmental factors like pollution and UV rays
  • Non-irritating and suitable for all skin types
  • Has a generous 60-day money-back guarantee
  • Major studies support the anti-wrinkle results of Stemuderm
  • This company offers the Quick Starter Travel Pack to try the product
  • Customers are not required to sign up for an auto-shipping delivery plan


  • There are no offline retailers who sell Stemuderm
  • Stock is sometimes low due to high consumer demand

The Bottom Line

When it came to selecting the best wrinkle cream on the market, Stemuderm was a clear choice. In a survey, 89% of users showed a noticeable reduction in apparent wrinkle depth within 4 weeks. This professional-grade, dermatologist-developed treatment is rich in powerful anti-aging ingredients that deeply hydrate the skin, leaving it plump and smooth, with a youthful fullness.

Fast-absorbing and non-greasy, Stemuderm has been proven to produce visible results within just a few weeks of use. 97% of users reported a reduction in fine lines within the first 4 weeks. 81% of users said their crow’s feet diminished significantly and that their skin remained smooth and wrinkle-free within just 4 weeks.

eyes-before-after head-before-after

Because the Stemuderm formula is all-natural, with no synthetic substances or common irritants, it is suitable for all skin types, even sensitive skin. Many users note that it reduces redness in the skin, giving their complexion a clear, even tone that appears overall healthier.

Stemuderm is made by the reputable skincare company Solvaderm, which backs all its treatments with a 100% satisfaction guarantee. Stemuderm does what it promises to, eliminating all lines and wrinkles quickly while providing long-lasting results that ensure your skin remains smooth, refreshed, and rejuvenated!

Stemuderm Customer Reviews Over The Internet


Here Sherri's Amazing Story

“My Skin Feels Silky Smooth, Young, And Lively, Thanks To Stemuderm!”

Sherri L., Age 47
5 Star

Here Helen's Amazing Story

“Within The 1st Week Of Using It, My Skin Started Feeling Softer And Looked Brighter.”

Helen B., Age 50
5 Star

Reduces sebum production

Sandra K. 5 Star

"Stemuderm was exactly the product I was looking for because I have a condition that results in the overproduction of sebum by my skin. You might be wondering why it's so perfect and that is because it contains jojoba oil. Jojoba oil reduces natural sebum production by the skin since it resembles it in chemical structure. In addition to this main benefit of using it, I also notice that I am not as oily throughout the day, and my skin still seems perfectly moisturized. My acne pimple marks that were left behind are also less visible than they were before using Stemuderm, which I greatly appreciate. I am not past the age of 40, but I know it is a good idea to start taking care of my skin now. If you are looking for an excellent moisturizing and anti-aging face cream I would suggest you give it a shot. If you don’t get results after a bottle, then just stop- but I am sure you will love it." **


A little goes a long way

Jo K. 5 Star

"In the past anytime I purchased an antiaging facial cream I would slather on thick amounts of it on my face in hopes of getting a superior result, but in reality, it turns out that it doesn’t really make a difference. Since I started using Stemuderm the first appreciate it was the fact that it does not take a large amount to get the job done. In fact, an amount smaller than a quarter is sufficient for application to your entire face. Of course, it also has to be very effective at doing its job or as I wouldn’t even be using it. It is excellent at hydrating my skin, and overall the appearance of fine lines around my eyes and mouth have been minimized. You do need to be consistent in using it, however, I learned this the hard way because I was using it once every couple of days and was not seeing anything, but once I started using it daily the results quickly became noticeable." **

Miami MD
#2 Miami MD
  • Diminishes Wrinkles & Fine Lines

  • Promotes Skin Cell Regeneration

  • Boosts Hydration

  • Promotes Good Skin Health

  • Improves Skin Tone & Texture


  • Has many positive customer reviews
  • It was formulated by doctors


  • It is only available from the official website
  • The customer service department may be hard to contact
  • It may irritate sensitive skin
  • Ingredient amounts aren’t disclosed

The Bottom Line

Overall, the anti-aging treatment Miami MD appears to be a well-made and not overly expensive cream that provides multiple benefits for the skin. However, there are some negative aspects regarding the product too, with reports of it causing irritation for individuals with sensitive skin, and even a few consumers saying it made their complexion dry, which is the opposite of what a cream of this type should do. It would also be helpful if the manufacturer offered free samples of their cream and while there is a refund policy, some individuals have said that contacting the company’s customer service department is difficult.

#3 Drmtlgy
  • Diminishes Wrinkles & Fine Lines

  • Promotes Skin Cell Regeneration

  • Boosts Hydration

  • Promotes Good Skin Health

  • Improves Skin Tone & Texture


  • Products in the range are suitable for all skin types
  • There is a 60-day money back guarantee


  • Drmtlgy products aren’t available in retail stores
  • Clinical study data for product formulas is not available
  • Drmtlgy is more expensive than comparable brands
  • Independent customer reviews are limited

The Bottom Line

The Drmtlgy brand offers several different skincare treatments, including a cleanser, SPF cream, and Needle-less serum, which according to the manufacturer is their best-selling product. The website for the brand is well-produced and reasonably informative and the formulas certainly contain some popular anti-aging key ingredients. However, the products are more expensive than similar brands and there is no solid evidence of successful clinical results provided on the website for prospective customers to review before making a purchase.

Your skincare routine is only as good as the products you use. Good, high-quality products are safe and effective and may come in particular formulations for sensitive skin and other issues. They can improve the texture and appearance of your skin while protecting it from the effects of the sun, pollutants, and other problems that can also have a negative impact on your health. Below you will find our subjective assessment of the Defenage based on the strength of the available information and our estimation of its efficacy for the Defenage.

  • Diminishes Wrinkles & Fine Lines
  • Promotes Skin Cell Regeneration
  • Boosts Hydration
  • Promotes Good Skin Health
  • Improves Skin Tone & Texture

Overall Rating

Try It

Stemuderm - A Better Alternative?

Diminishes Wrinkles & Fine Lines
Promotes Skin Cell Regeneration
Boosts Hydration
Promotes Good Skin Health
Improves Skin Tone & Texture

In a survey, 89% of users showed a noticeable reduction in apparent wrinkle depth within as little as 28 days of regular use. Stemuderm dramatically reduces signs of aging on all areas of the face, including the forehead, cheeks, and around the mouth and eyes. Stemuderm transforms the skin within weeks, making it visibly firmer, evenly toned, and overall more youthful. 97% of users reported a reduction in fine lines while 81% of users said their crow’s feet diminished significantly within the first 4 weeks. Stemuderm also provides long-lasting protection for the skin with its inclusion of innovative plant-based growth enzymes which, as numerous studies have shown, radically slow the aging process and increase skin cell longevity. When used twice a day as recommended by the manufacturer, Stemuderm has been proven to produce significant results, with many users seeing benefits within the first few applications. You can find out more about Stemuderm now.

Read More About Stemuderm Nowarrow

Final Words

DefenAge is an anti-aging eye cream formulated with ingredients that may stimulate dormant skin cells, nourish, and fight off aging signs. The product is made by a known brand, claimed to be free of additives, and enjoys many reviews on the official website even though expensively priced. While DefenAge reviews on some independent sites have been mixed, many reviewers claim to have noticed improvements in their aging signs within just weeks of use. We advise that potential buyers do their due diligence before purchase if DefenAge is within their budget. If not, you can check out other similar products and pick a more suitable alternative.

**The above is a subjective review. Our opinion of the product’s efficacy was based on independent research and information.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

Disclosure of Material Connection : Products shown in the section titled ‘Our Top Choice’ are those that we promote as the owner and/ or reseller and does not represent all products currently on the market or companies manufacturing such products. This information is disclosed in accordance with the Federal Trade Commission’s 16 CFR, Part 255 “Guides Concerning the Use of Endorsements and Testimonials”. We would like to make it clear that any and all links featured in this section are sales links; whenever a purchase is made via one of these links, we will receive compensation.

*Result may vary. The information contained in this website is provided for general informational purpose. No medical claims are implied in this content, and the information herein is not intended to be used for self diagnosis or self treatment of any condition.

† Based on an internal customer response survey of subgroups of individuals. This is a subjective survey and in no way should it be intended to be interpreted as a clinical study. Results may vary.


Get the latest in healthy living, nutrition & fitness, mental wellbeing, beauty & skincare, and more, straight to your inbox!



Your Privacy is important to us

Disclaimer: The content published on our website is to inform and educate the reader only and is not a substitute for professional medical advice from your doctor or other health care provider. If you have a specific health question or concern you must consult with a qualified medical professional and in the case of an emergency, immediately contact your local emergency services. The publishers of this website and the content take no responsibility for any detrimental health issues or injuries that result from following advice found in articles, reports/overviews, or other content on our website. All opinions expressed on this website are the opinions of the owners of this website. Many products and services featured on this native advertising site are selected by our editors which means we may get paid commissions on many products purchased through links to retailer sites via native advertising, this is disclosed throughout all relevant pages of the site. All trademarks, registered trademarks, and service marks mentioned on this site are the property of their respective owners. © 2022. All Rights Reserved.


All Health Web Magazine content is thoroughly reviewed and/or fact-checked by a team of health industry experts to ensure accuracy.

In keeping with our strict quality guidelines, we only cite academic research institutions, established health journals, or peer-reviewed studies in our content. You will be able to find links to these sources by clicking the numbers in parentheses (1, 2, etc.) that appear throughout our content.

At no time do we advise any of our readers to use any of our content as a substitute for a one-on-one consultation with a doctor or healthcare professional.

We invite you to contact us regarding any inaccuracies, information that is out of date or any otherwise questionable content that you find on our sites via our feedback form.