ColonBroom GLP-1 Booster contains four active ingredients — all fully disclosed on the label with no proprietary blend. The formula is vegan, gluten-free, stimulant-free, and contains no synthetic hormones or GLP-1 receptor agonists. Each bottle contains 60 capsules — a 30-day supply at the standard 2-capsule daily serving.
1. Berberine Hydrochloride (from Berberis aristata bark)
Berberine is a plant alkaloid derived from Barberry (Berberis aristata) and is the primary active ingredient in the ColonBroom GLP-1 Booster formula. It is one of the most extensively studied botanical compounds for metabolic support — with multiple randomized controlled trials examining its effects on blood sugar regulation, insulin sensitivity, and gut microbiome modulation.
Its relevance to GLP-1 support is mechanistically direct: a published study found that berberine stimulates GLP-1 secretion from intestinal L-cells — the cells responsible for producing GLP-1 in response to food — meaning it may help support the body’s own natural appetite signalling rather than introducing an external hormone.
Berberine also activates AMPK (AMP-activated protein kinase) — often described as the body’s “metabolic master switch” — which helps regulate glucose uptake into cells, fat oxidation, and mitochondrial energy production. Beyond metabolic function, berberine supports a balanced gut microbiome by modulating the ratio of beneficial to pathogenic bacteria — contributing to the gut-metabolism connection the formula is built around.
2. Resveratrol (from Polygonum cuspidatum, standardised)
Resveratrol is a polyphenol found naturally in the skin of red grapes, Japanese knotweed (Polygonum cuspidatum), and other plant sources. In the ColonBroom GLP-1 Booster formula, it works as a metabolic sensitiser rather than a direct GLP-1 stimulator — supporting the body’s capacity to produce and respond to GLP-1 more effectively when triggered by a meal.
Its primary mechanisms include improving insulin sensitivity through SIRT1 activation, supporting healthy fat metabolism and adipogenesis regulation, and reducing low-grade systemic inflammation that can impair metabolic signalling pathways. Resveratrol’s anti-inflammatory properties are particularly relevant in the context of metabolic health — chronic low-grade inflammation is closely associated with insulin resistance and dysregulated appetite signalling. Multiple randomized controlled trials have explored resveratrol’s effects on markers of metabolic health, with the most consistent evidence for improvements in insulin sensitivity and fasting blood glucose in overweight adults.
3. Quercetin Dihydrate (from Sophora japonica)
Quercetin is a flavonoid derived from the Japanese pagoda tree (Sophora japonica) and several other plant sources. In the ColonBroom formula it performs a dual function — complementing berberine’s direct GLP-1 stimulation through a distinct mechanism that helps extend the hormone’s activity.
Quercetin is a natural DPP-4 inhibitor — DPP-4 (dipeptidyl peptidase-4) is the enzyme responsible for rapidly breaking down GLP-1 after its release. By inhibiting this enzyme, quercetin prolongs the half-life of naturally secreted GLP-1, allowing the “fullness signal” to persist longer after meals. This is the same mechanism targeted by a class of prescription diabetes medications (gliptins/DPP-4 inhibitors) — though quercetin’s effect is considerably more modest than pharmaceutical DPP-4 inhibition.
A published study confirmed quercetin’s role in supporting appetite regulation and GLP-1 pathway activity through its DPP-4 inhibitory mechanism. Quercetin also provides broad anti-inflammatory support and has been studied for its role in supporting cardiovascular and immune health.
4. Zinc Citrate
Zinc is an essential trace mineral included in the ColonBroom GLP-1 Booster formula as a foundational cofactor for several metabolic processes directly relevant to appetite regulation, gut health, and insulin function. It is delivered as zinc citrate — a highly bioavailable chelated form that supports efficient absorption compared to zinc oxide or zinc sulfate forms commonly used in lower-quality formulas.
Zinc plays a structural and functional role in insulin — each insulin hexamer contains two zinc ions, and zinc is required for the proper storage, secretion, and action of insulin in the pancreas. Deficiency in zinc is associated with impaired insulin sensitivity and dysregulated appetite signalling. Zinc also supports gut barrier integrity (zinc deficiency is associated with increased intestinal permeability), modulates immune function within the gut, and contributes to the healthy microbiome diversity that underpins the formula’s gut-metabolism approach. A systematic review published in Nutrients confirmed that zinc supplementation significantly improved fasting blood glucose and insulin resistance markers in adults with metabolic concerns.
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